Stimulation of repetitive calcium transients in mouse eggs.
نویسندگان
چکیده
منابع مشابه
Repetitive calcium transients in hormone-stimulated cells.
Many hormones that act via the phosphoinositol .cycle induce transient rises in cytoplasmic free Ca2+ in a variety of cell types (Berridge et al., 1988). To this list may now be added vascular smooth muscle cells from rat and rabbit aorta in primary culture; both angiotensin I 1 and ATP induce repetitive free Ca2+ transients in spread single cells microinjected with aequorin (Fig. 1). The mecha...
متن کاملThapsigargin activates a calcium influx pathway in the unfertilized mouse egg and suppresses repetitive calcium transients in the fertilized egg.
At fertilization, the sperm initiates development of the mouse egg by inducing a large transient increase in the intracellular Ca2+ concentration ([Ca2+]i), which is followed by repetitive transient increases in [Ca2+]i. To determine how the repetitive Ca2+ transients are produced, thapsigargin, an inhibitor of the endoplasmic reticulum Ca-ATPase, was used to deplete intracellular Ca2+ stores w...
متن کاملRepetitive sperm-induced Ca2+ transients in mouse oocytes are cell cycle dependent.
Mature mouse oocytes are arrested at metaphase of the second meiotic division. Completion of meiosis and a block to polyspermy is caused by a series of repetitive Ca2+ transients triggered by the sperm at fertilization. These Ca2+ transients have been widely reported to last for a number of hours but when, or why, they cease is not known. Here we show that Ca2+ transients cease during entry int...
متن کاملA cytosolic sperm factor stimulates repetitive calcium increases and mimics fertilization in hamster eggs.
Microinjection of cytosolic sperm extracts into unfertilized golden hamster eggs caused a series of increases in cytoplasmic free calcium, Ca2+i, and membrane hyperpolarizing responses, HRs. These HRs and Ca2+i transients are similar to those seen during in vitro fertilization of hamster eggs. The sperm factor that is responsible for causing these effects appears to be of high molecular weight ...
متن کاملMechanism of intracellular calcium transients.
Calcium ions mediate extracellular signals on intracellular processes. The signalling system based on transient rises or oscillations of the cytoplasmic calcium concentration has potential advantages. The relevant mechanisms of intracellular concentration changes include calcium-induced calcium release and calcium dependent inactivation of calcium release. A model has been devised based on thes...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1995
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1995.sp020589